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Xia L, Nordman T, Olsson JM, Damdimopoulos A, Bjorkhem-Bergman L, et al
The gene family members share multiple conserved motifs, including the Gly-x-Ser-x-Gly lipase consensus sequence, a catalytic Ser-Asp-His triad, cysteine residues responsible for intramolecular disulfide bond formation, and lipid binding surface loops, including the lid domain and the 9 loop ( Fig
In patients with McCune-Albright syndrome or pigmentary mosaicism of other etiologies, CALMs may have a segmental distribution with sharp midline demarcation and an irregular, jagged outline (coast of Maine)
