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The decision to use a weight loss medication is a personal decision that requires shared decision-making between you and your clinical provider

It is also wise to avoid consuming foods that make you feel bloated or gassy, particularly when you increase your dosage

Each trial layers on its own inclusion criteria

So if you were on a full maintenance dose, stopped for a couple of months, and then jumped straight back to that full dose, your gut would be meeting a large dose again with little of the adaptation it had before

2C) was 1.00 at 6 months, 0.87 at 12 months, 0.64 at 18 months, and 0.49 at 24 months in not treated subjects

Hydration and Electrolyte Balance Reduced appetite may also lead to lower fluid intake