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In sum, it is worthy to note that lipid peroxidation (LPO) products such as 4-hydroxynonenal (4-HNE) and malondialdehyde (MDA) arise as secondary messengers of oxidative stress, which is often counterbalanced by the cellular antioxidant defense system [133]

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doi: 10.1080/01635580903285098 23 KampaMNifliAPNotasGCastanasE

Gastroenterology 138(5):17721782

Mechanistic basis for impaired Ferroptosis in cells expressing the African-centric S47 variant of p53