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PLP, Pyridoxal 5-phosphate (or P5P)

According to Rysz and colleagues, as CKD progresses, protein-bound uremic toxins, such as IS, p-CS, p-cresyl glucuronide, and indole-3-acetic acid (IAA), gradually accumulate

However, because it is a large molecule, it may struggle to penetrate the skin deeply

Abbreviations : QD, once a day

Exposure to pro-oxidant stimuli usually induces Nrf2 activation and upregulation of antioxidant enzyme expression through binding to the antioxidant response element (ARE), localized in the antioxidant enzyme gene promoters