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Efficacy and safety of the combination of glucosamine and chondroitin for knee osteoarthritis: a systematic review and meta-analysis

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Among the top 12, the biggest climbers were AstraZeneca, Eli Lilly, and Novo Nordisk

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We began with the most challenging endpoint possible (extension of median and maximal lifespan) in a very rigorous, well-controlled study (the NIA ITP), checked that rapamycin performed well in that setting, then only afterward began considering individual, smaller, less well-controlled studies of alternate endpoints like muscle mass and hearing loss