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The MHRA-approved indications for these medications are limited to type 2 diabetes mellitus and, for certain formulations, obesity management in adults with specific BMI thresholds as detailed in their SmPCs

Explain the basics of how the medications work

Based on Phase 2 trial protocols, the standard approach looks like this: Weeks 1 to 4: 1 mg once weekly Weeks 5 to 8: 2 mg once weekly Weeks 9 to 12: 4 mg once weekly Weeks 13 to 16: 8 mg once weekly Weeks 17 onward: 12 mg once weekly (if tolerated) That is a minimum 16 to 20 week ramp-up to reach the maximum dose, compared to a similar timeline for Ozempic

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[2] Examples of nutrient-dense foods include vegetables, fruits, whole grains, seafood, eggs, legumes, unsalted nuts and seeds, low-fat dairy products and lean meats

One of the main reasons for discontinuation was perceived excessive weight loss, per Dr