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Similarly, recruitment of participants with severe hepatic impairment into the hepatic impairment study was challenging and, despite a third study site being added and the recruitment period being prolonged, it was not possible to complete recruitment of seven participants into the severe hepatic impairment group

The inhibitory subunit of NE2FL2, Keap1, is a cysteine-rich protein that serves as a redox sensor and can bind to p62 and be degraded by autophagic activity

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It stimulates collagen production in dermal fibroblasts by up to 70% at optimal concentrations around 1 nanomolar