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114 In a controlled study enrolling 20 participants who received the VLCKD, a significant improvement in biochemical parameters was observed after 8 weeks of KD adherence, which included a reduction in BMI, LDL-C, TGs, insulinemia, and liver transaminases

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Evidence for this IGF1R-dependent activity of IGFBPs is complemented by many studies showing antiproliferative and pro-apoptotic effects of IGFBPs acting independently of the modulation of IGF1R signaling