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These findings are supported by in vitro research by Finamore et al

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Moreover, NRF2 is required for the survival of hematopoietic stem progenitor cells (HSPCs) and the development of myeloid cells in mice, as NRF2 KO bone marrow had defect in stem cell function and showed reduction of chimerism after transplantation [124]

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Collectively, bioinformatics-driven multi-omics platforms provide a powerful framework for delineating the multifaceted pharmacological actions of natural compounds and accelerating the development of precision medicine strategies for AD