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10.1016/j.pneurobio.2013.07.007 333

In addition, Myc-dependent expression of ATF4 in DLBCL cells, human colon adenocarcinoma cells, and mouse embryonic fibroblasts drives the expression of SLC1A5 during metabolic adaptation to stress conditions 73,80,81

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In patients taking opioids for an extended period of time at high doses, ensure that a multimodal approach to pain management, including mental health support (if needed), is in place prior to initiating an opioid analgesic taper [see DOSAGE AND ADMINISTRATION, and WARNINGS]