Study population Female patients aged 2040 years were identified based on a documented fertility-related encounter, defined as a medical visit associated with a diagnosis of female infertility, an encounter for procreative management (encompassing general counseling, fertility testing, and ART surveillance), or specific fertility treatments (e.g., intrauterine insemination, oocyte retrieval) (see codes in Supplementary Table S1)
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Interestingly, both GLP-1R agonists and SGLT2 inhibitors suppressed PIO-induced weight gain to statistically insignificant levels between the comparing groups, suggesting that both drug categories can exert additional beneficial effects in treating NAFLD beyond weight reduction
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The body sometimes needs a second attempt to tolerate a given dose level, and there is no penalty for taking the escalation more slowly than the standard schedule suggests
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