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After removal of clearly nonrelevant records based on title and abstract screening, approximately 40 to 70 studies were identified as potentially relevant to musculoskeletal biology, orthopaedic care, or perioperative considerations

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Known mechanisms underlying estrogenic effects in skin repair are summarized in Table 1 and Figure 1

Thanks to all the members of the Butler and Wolfe group for the comments on the manuscript

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The activation and proliferation of glial cells, in turn, are useful in order to release signaling factors and to trigger a robust immune reaction consisting of brain-resident as well as peripherally recruited inflammatory cells