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Bottom line 10mg vial: 1 ml BAC water (10 mg/ml) 2.5 mg = 25 units 20mg vial: 1 ml BAC water (20 mg/ml) 2.5 mg = 12.5 units 30mg vial: 1.5 ml BAC water (20 mg/ml) 2.5 mg = 12.5 units Start low: hold 2.5 mg for weeks 1-4, then bump every 4 weeks Common ceiling: 15 mg / week in educational schedules Write it down: data beats guessing References Jastreboff, A.M., et al

Endocrinology (2018) 159:170417

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H2O2 stimulates Cl /HCO3 exchanger activity through oxidation of thiol groups in immortalized SHR renal proximal tubular epithelial cells