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The peptide's research profile has expanded from its origins in gastrointestinal cytoprotection, first described by Sikiric et al., to a broad range of tissue repair applications

GHK-Cu blocked the LPS-induced nuclear translocation of NF-B p65 and phosphorylation of NF-B p65 in LPS-induced RAW 264.7 cells activation NF-B plays an important role in the LPS-induced expression of pro-inflammatory proteins