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Semaglutide Semaglutide, a GLP-1 receptor agonist (GLP-1 RA), has demonstrated remarkable efficacy in managing weight and improving glycemic control in individuals with Type 2 diabetes mellitus (T2DM) and obesity (23)(39)
GLP-1 drugs mimic the hormone and activate the GLP-1 receptor to control appetite and blood sugar
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The secondary outcomes comprising cardiometabolic risk factors (including high-density lipoprotein cholesterol (HDL-C), triglycerides (TG), body mass index (BMI), insulin sensitivity index adjusted for BMI (ISI), systolic blood pressure (SBP), diastolic blood pressure (DBP)) [33] and multiple-organ complications (liver diseases: metabolic dysfunction-associated steatohepatitis, liver fibrosis, fibrosis in MASLD, liver cirrhosis, hepatocellular carcinoma (HCC), hepatic failure
