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The head of SR146131 overlies the pocket formed by TM6ECL3TM7, and foot A (phenyl ring) stands on TM3TM6, whereas foot B (cyclohexane ring) stands on TM2 and TM7 (Fig

Mol Pharmacol 82 : 271280

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The concordance between the proteomic profile and the alterations observed in oxygen consumption, mitochondrial membrane potential, mitochondrial morphology, cellular redox balance, proliferation, migration, and apoptosis provides a coherent framework for unravelling the biological effects of this compound