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Ridotto apporto (evenienza che pu verificarsi quando si seguono diete scorrette o inadeguate, quando si sottoposti a nutrizione parenterale protratta per lunghi periodi, ecc.)

The side effects and the benefits come from the exact same mechanism

In clinical applications, in addition to treating T2DM, metformin has been found to be effective in certain diseases, such as obesity, cardiovascular disease, IBD, and other inflammation-related diseases

Nuclear-translocated p65 directly promotes the expression of downstream proferroptosis genes (e.g., Cox-2), driving ferroptosis in lung epithelial cells and synergistically promoting M1 macrophage polarization, thereby exacerbating lung injury (Ling et al., 2023)

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And he goes, well, that's what I'm saying, bro