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First, the causal relationship between changes in TMAO concentration and heart and kidney failure and CRS is uncertain

2011;3:CD007749

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By demonstrating protective effects in a ciliopathy model, this study suggests that GLP-1 RAs may confer benefits beyond appetite suppression in patients with genetic obesity syndromes affecting ciliary function, further broadening the mechanistic rationale for targeting this pathway across diverse genetic etiologies of obesity