Also in September 2025, FDA established a Green List Import Alert (66-80) to help stop GLP-1 APIs that have potential quality concerns from entering the U.S
This is a recurring hazard in neurodegeneration drug development, where surrogate measures are seductive precisely because clinical endpoints are slow, noisy, and expensive to move
Overall, complex I appears to be most affected in autistic patients whereas complex II is least affected [128]
Animal studies have shown that it may cause fat to accumulate where it shouldnt, causing liver problems or oxidative stress
Symptoms include hives, urticaria, facial swelling, and in severe cases, anaphylaxis
[5] [6] ALA is available in both R-lipoic acid and racemic (R/S) forms