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Interestingly, even heterozygous Bbs5 +/ mice, which displayed normal body composition and energy metabolism compared with WT controls (Supplemental Figure 1, KV), were resistant to leptin (Supplemental Figure 3, K, L, O, and P), suggesting that leptin resistance may serve as a potential biomarker even in individuals with a single Bbs gene mutation
We Rashi Pharma Care Private Limited
Chemosphere 147:131137
510 Nedosiran, another RNAi drug developed by Dicerna Pharmaceuticals that targets LDHA, is currently being evaluated for its efficacy in reducing oxalate production
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These tablets dissolve in the stomach before absorption which means their bioavailability (absorption rate) depends on digestion and formulation quality
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