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Oral and topical forms show benefits, but results vary by individual and skin color

793,794 Increased intracellular iron levels are a key factor promoting lipid peroxidation and ferroptosis in cardiomyocytes

Supporting our cytochrome c assays, we confirmed no change in mitochondrial outer membrane permeabilization (MOMP) in cells surviving 5FU treatment (compared to the dimethyl sulfoxide group), and no increase in mitochondrial apoptotic priming based on BH3-profiling 15,16 induced by 5FU treatment (Extended Data Fig

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This is unusual for peptides, which are typically degraded in the gastrointestinal tract