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Because vitiligo affects physical appearance, living with the condition can be challenging and can affect emotional well-being

& Vazquez, C

Slowed weight loss creates its own stress, which then perpetuates the plateau

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The Research Goal: Is the study looking for a minimal effective dose or a maximum tolerated dose

It has been proposed that leptin exerts a negative regulatory effect on the release and action of ghrelin and that an increase in ghrelin level induced by fasting or weight loss arises because of the diminished inhibitory effect from leptin and probably also from PYY