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5 Conclusion In summary, GLP-1RAs have revolutionized obesity and diabetes management, offering potent weight loss and cardiometabolic benefits, but are best used in conjunction with lifestyle interventions, particularly exercise, to optimize health outcomes and sustainability

I-intervention: In vitro studies undertaken to analyze the role of short peptides in the pathogenesis and treatment of oral diseases, including their potential applications in anti-cancer therapy

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GLP-1RA ameliorates HFD/PA-induced PPAR downregulation in Islets and NIT-1 cells To elucidate the mechanisms underlying the improvement in glucose homeostasis and pancreatic islet function by GLP-1RA, we conducted RNA-Seq analysis of the pancreatic islets of mice in the NC + saline, HFD + saline, and HFD + Exe groups

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