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In one study, adjusted odds ratios for MASLD demonstrated a clear gradient: lowest in never smokers, higher in exclusive cigarette smokers, and highest among dual users, suggesting an additive or even synergistic effect of combined exposure [140]

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J Contemp Dent Pract 4:7686 Meleti M, Vescovi P, Mooi WJ et al (2008) Pigmented lesions of the oral mucosa and perioral tissues: a flow-chart for the diagnosis and some recommendations for the management