tirzepatide discontinuation weight regain Causes and consequences of of GLP1RAs or Tirzepatide Demonstrates Sustained Weight Loss

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The rationale is that glucagon also increases energy expenditure and promotes hepatic fat mobilization, so a molecule that combines glucagons metabolic-rate effect with GLP-1/GIPs appetite-and-glucose control can, in principle, drive weight loss from both sides of the energy-balance equation at once

1986 Nov-Dec;3(6):383-8

Oral semaglutide reduces appetite and energy intake and improves control of eating in subjects with type 2 diabetes

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