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These contraindications apply to all GLP-1 agonists and extend to combination protocols

Several studies have shown that, in addition to alterations in dopaminergic and cholinergic transmission (82), the 5-HTergic system may also be a key factor primarily linked to negative symptoms in schizophrenia (21)

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Additionally, recent clinical evidence has demonstrated that newly diagnosed hypothyroid individuals exhibit elevated malondialdehyde (MDA) and decreased total antioxidant capacity, supporting the link between impaired antioxidant status and heightened oxidative stress (Sultana et al

doi: 10.1023/a:1015555023692

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