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R 4-OH catechol estrogens that are not methylated by COMT can be oxidized to quinones that generate reactive oxygen species and form DNA adducts, a mechanism implicated in estrogen-dependent cancers

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Sources: Tirzepatide Once Weekly for the Treatment of Obesity | New England Journal of Medicine Realworld use and effectiveness of tirzepatide among individuals without type 2 diabetes: Results from the Optum Market Clarity database PMC Semaglutide vs Tirzepatide for Weight Loss in Adults With Overweight or Obesity | Obesity | JAMA Internal Medicine | JAMA Network Semaglutide StatPearls NCBI Bookshelf Safety of Semaglutide PMC Semaglutide, a glucagon like peptide-1 receptor agonist with cardiovascular benefits for management of type 2 diabetes PMC Realworld evidence on the utilization, clinical and comparative effectiveness, and adverse effects of newer GLP1RAbased weightloss therapies PMC Liraglutide for weight management: a critical review of the evidence PMC Liraglutide and not lifestyle intervention reduces soluble CD163 after comparable weight loss in obese participants with prediabetes or type 2 diabetes mellitus PMC Effect of Continued Weekly Subcutaneous Semaglutide vs Placebo on Weight Loss Maintenance in Adults With Overweight or Obesity: The STEP 4 Randomized Clinical Trial | Clinical Pharmacy and Pharmacology | JAMA | JAMA Network

The emerging role of the Nrf2-Keap1 signaling pathway in cancer