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Among the diversity of products with flame-retardant properties, polybrominated diphenyl ethers (PBDEs) were the most commonly used until their production and use were phased out in the EU and the USA in 2004 due to concerns about neurotoxicity and metabolic deregulation [232,233,234]
The intracellular and the microenviromental molecular signalling pathways that drive the development of oral mucosal melanin pigmentation remain largely unknown [7]
For more frequent symptoms, histamine-2 receptor antagonists (H2RAs) such as famotidine may be used, though patients should be counseled that these medications may take 30-60 minutes to provide relief
Coverage: consider your population and your benefit portfolio objectives
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These systems allow for more versatile activation mechanisms Fig
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