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Some patients with osteoarthritis are reporting changes in stiffness, flare-ups, and activity tolerance before any meaningful weight loss has been achieved

Approximation of the slopes and intercept allowed estimation of apparent K m and V max values from Lineweaver-Burk and Hofstee linear plots were: 27.62 M and 0.66 nmoles ml -1 min -1

That applies to both regular semaglutide and tirzepatide, as well as popular combination versions like semaglutide mixed with vitamin B12