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Expression in other tumor types, including malignant insulinomas, appears to be variable (reviewed in Ref

The findings suggest that GLP-1 drugs may have anti-inflammatory effects independent of their role in glucose regulation

It also plays a crucial role in reducing the nausea and gastrointestinal discomfort often associated with high-dose GLP-1 therapy

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Importantly, not all variants confer increased risk: loss of function variants in HSD17B13, a lipid droplet-associated protein in hepatocytes, have been consistently associated with reduced hepatic inflammation and a lower risk of fibrosis and advanced liver disease [16]