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doi: 10.1113/jphysiol.2004.068197 149 HuhJYDincerFMesfumEMantzorosCS

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Although the atherosclerotic CV disease risk reduction and CKD progression benefits of SGLT-2 inhibitors may be found to be a class effect in future, the evidence for ertugliflozin (a third SGLT-2 inhibitor recently deleted from the market in Australia) is less robust with further studies ongoing

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EWAS were considered as inconsistent if they lacked a replication or validation cohort [24], while targeted studies were downgraded for this category if their results were in contradiction with the literature