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In osteosarcoma radiotherapy, selinexor inhibits CRM1, affecting PHD2 and targeting HIF-1, thereby increasing radiosensitivity 23,55 (Figure 2 and Table 1)

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Translation initiation at the 5AUG results in the generation of m-GPx4 isoenzyme, while translation from the 3AUG, that lacks this leader signal, yields c-GPx4

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