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Other assessment points with better correlation to AUC (especially for once-daily formulations) have been published, i.e., C6 as the most accurate single point or in combination with C2 as a two-point model for AUC0-12 (63) and C2 plus C10 for AUC0-24 (64), but have not yet gained acceptance in clinical practice, mainly due to practical reasons (65)

276 In addition, lipid metabolism disorders caused by high lipid levels lead to the dysregulation of GSH and ferroptosis of vascular smooth muscle cells

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