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[39] In chemical denaturation experiments, holo SOD1 unfolds by a three-state mechanism with observation of a folded monomeric intermediate

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In addition, low oestrogen status may reduce endogenous conversion of phosphatidycholine to choline (as reviewed by Derbyshire, 2019) suggesting that the menopause is a time when women experience a rapid change to the enzymatic control of endogenous choline production

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Results showed that catalytic activity was 3- to 4-fold higher for the GSTP1a variant than for either GSTP1b or GSTP1c