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Oxford Grice, K

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COA / Lab results Evidence: Clinical trial Pros Triple GLP-1 / GIP / glucagon agonism in one peptide raises energy expenditure, not appetite alone Largest weight reduction reported for an incretin-class compound (~24% at 12 mg, 48-wk phase 2) Reductions in HbA1c, visceral fat and liver-fat content across trials Once-weekly subcutaneous dosing (albumin-bound half-life) Cons GI effects require gradual multi-week dose titration Newest of the GLP-1 class phase 3 (TRIUMPH) topline only

doi: 10.1080/00480169.1998.36089

Researchers analyzed medical records from 606,434 US veterans (average age 65

Statistical analysis Statistical comparison of wool fineness and density was performed by the one-way ANOVA