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However, it is still unknown if soluble uric acid (sUA) activates the inflammasome complex and lead to IL-1 production
Krautz-Peterson et al
The preference of the (iso)peptidases for ubiquitin/SUMO/NEDD8/ISG15 was shown to be mediated by a so-called aromatic gatekeeper residue, i.e., a Trp, Phe or Tyr residue directly following the catalytic His base, sterically restricting active site access to an (iso)peptide bond formed between an ()-amino group in linear chains, or an ()-amino group in substrate lysine side-chains, and an ()-carboxyl group originating from the C-terminal di-Gly motif of a Ub or ubiquitin-like protein (Ubl) 20,21,26
following acute MI, prompt L-carnitine administration and subsequent oral maintenance therapy has been shown to attenuate progressive left ventricular dilatation and appears to reduce myocardial injury through improving carbohydrate metabolism and reducing the toxicity of high free fatty acid levels [5, 6]