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Wegovy is titrated to 2.4 mg weekly for weight management
doi:10.1111/j.1744-9987.1997.tb00142.x Senderovich H, Vierhout MJ
The STEP 1 extension study showed that participants who stopped semaglutide regained approximately two-thirds of their lost weight within a year
This was performed by high-pressure liquid chromatography using a LC-20A Shimadzu equipment (Shimadzu GmbH, Duisburg) with an interphase module (CBM-20A, Shimadzu GmbH) and electrochemical detection (ESA Biosciences, Inc., Chelmsford, MA), with the upstream electrode set at +100 mV (for compounds with low oxidation potential) and downstream electrode set between +100 and +650 mV (in +50 mV increments) for each injected standard to determine the optimum potential for detection
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Serum retinol alone is a poor indicator: it stays normal until liver stores are almost depleted, and it falls in inflammation even when stores are adequate
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