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The precise role of biotin treatment in THMD2 in unknown since the defect is in the transporter for cellular thiamine uptake

It is thought that the peptide may directly affect metabolism in such a way so as to reduce complications separate from its effects on obesity

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Hyperpigmentation is associated with numerous dermatological disorders and can present in various forms, such as melasma, post-inflammatory hyperpigmentation, and lentigines

While not curative on its own, chemotherapy may be considered for high-grade, metastatic, or unresectable tumors, or in the neoadjuvant (pre-surgical) setting

, GCLC , GSR , GSTs , and GPXs ), thereby reinforcing ferroptosis resistance 154-156