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Similarly, patients with Clostridium difficile infection, which has a high mortality rate and increases the chances of acquiring hospital-acquired diarrhea, also exhibited a significant depletion in butyrate producers such as Roseburia , Anaerostipes , Blautia , and Faecalibacterium , along with lowered butyrate levels (Antharam et al., 2013)

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Recent innovations have attempted to improve SOD supplementation effectiveness through several approaches: Liposomal encapsulation to improve stability and absorption SOD-rich extracts from plants like melon or wheat sprouts Combination with other antioxidants or delivery systems Gliadin-bound SOD formulations designed to resist digestion While these advances have improved SOD supplementation outcomes in some studies, hydrogen water generally offers advantages in terms of bioavailability, cost-effectiveness, and ease of administration for many applications

Cancer Res (2021) 81(19):498193