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Psychopharmacology (Berl) 60: 137-146

Ironically, a side effect of excessive anticholinesterase treatment is excessive weakness or cholinergic crisis due to excessive stimulation of nicotinic receptors in the muscle end-plate region, resulting in a transient phase of uncontrolled muscle fasciculations due to sustained depolarization, followed by the development of receptor desensitization and a flaccid paralysis

This is crucial context because it explains why AOD 9604 works better as part of a combination strategy rather than as a standalone fat loss solution

This represents the amount sufficient to meet the needs of approximately 97% of the population

Currently, Triluma (hydroquinone 4%, tretinoin 0.05%, fluocinolone acetonide 0.01%) is the only triple combination therapy approved in the USA for melasma [6, 205]

43 JelinekA.HeyderL.DaudeM.PlessnerM.KrippnerS.GrosseR.et al (2018)