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Safety-first, evidence-forward guidance for GLP-1s
Parizad et al., 2025)
Liraglutide, the glucagon-like peptide-1 receptor agonist, has anabolic bone effects in diabetic Goto-Kakizaki rats
This included Israel Simon Kleiner and Samuel Meltzer, two American physiologists, based at the Rockefeller University in New York who in 1915 demonstrated with animal experiments the power of intravenously administered pancreatic extracts in lowering blood sugar
5 For example, recent preclinical and clinical observations highlight the role of gut-derived peptides such as GIP, GLP-2, and to a lesser extent, GLP-1 in the maintenance of overall skeletal health ( Figure 2 ), 6,7,8 opening new avenues for the understanding and potential treatment of bone disorders
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