This tightly regulated process begins with signal detection by microglia through pattern recognition receptors (PRRs), such as toll-like receptors (TLRs), or other damage associated receptors, such as receptor for advanced glycation end products (RAGE) and scavenger receptors, prompting a transition from a surveillant to a reactive state (Kraft and Harry, 2011)
In the context of medication usage for symptom management, it is important to acknowledge that several of the top 100 prescribed drugs in South Africa have been found to deplete various nutrients
Kerchenski and C
Cell Rep 2018;24, 19391948 e1934, doi: Brelstaff, J
Vinciguerra F, Di Stefano C, Baratta R, et al
However, they are currently only used to treat thalassemia iron overload caused by excessive blood transfusions (Kontoghiorghes and Kontoghiorghe, 2020)