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Novo Nordisk announced FDA acceptance of their New Drug Application (NDA) for a 25 mg oral version of Wegovy for two new indications: (1) chronic weight management in adults living with obesity or who are overweight with at least one comorbid condition, and (2) to reduce the risk of MACE in adults with overweight or obesity and established CVD

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No dose adjustment is required in renal impairment according to the UK SmPC, though renal function should be monitored, especially if significant gastrointestinal adverse effects or dehydration occur

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Weight-loss plateaus typically last 412 weeks and are not a sign of treatment failure