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Safety Considerations and Clinical Eligibility Factors Both platforms screen for contraindications, including personal or family history of medullary thyroid cancer, multiple endocrine neoplasia type 2, and severe renal or hepatic impairment

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The vagus nerve serves as a critical communication pathway, transmitting gut-derived signals to both brain and kidney tissues, and its activation modulates renal sympathetic tone and inflammatory responses (Keefer, 2018)

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