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TRAP1 drives smooth muscle cell senescence and promotes atherosclerosis via HDAC3-primed histone H4 lysine 12 lactylation

The clearance of senescent cells via senolytics (e.g., dasatinib/quercetin, fisetin) presents a transformative strategy to attenuate the pro-inflammatory and pro-catabolic SASP that damages both muscle and vasculature, with several clinical trials already underway (186)

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Such adjustment analyses could not be conducted due to lack of number of studies reporting mortality outcomes

However, for animal studies, we evaluated both male and female mice

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