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The findings of the current study should be interpreted in light of several limitations

It works by inhibiting melanin production, shifting melanin synthesis from darker eumelanin to lighter pheomelanin, and reducing oxidative stress in skin cells

Statins work in part by interfering with the synthesis of cholesterol in the liver, and they also reduce the cholesterol saturation of bile (Cariati 2012

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2c), while mutating L178 4.60 or I181 4.63 to Asp diminishes the activities by only ~5-fold and 20-fold, respectively (Fig