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The cardioprotective mechanism proposed involves the enhancement of mitochondrial function, the reduction of oxidative stress, the attenuation of inflammation, and the inhibition of apoptosis (Luna-Marco et al., 2023

(TIF) Figure S7

doi: 10.3389/fphys.2017.00377 47

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These responses are known to be directed to specific sequences in the TPO molecule, including epitopes at aa 110-129, 210-230, 420-439, and 842-861(18)

However, there is a relative lack of literature related to the potential mechanisms of mitophagy and MAFLD, and future studies are still needed to explore their specific mechanisms in depth