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Although the genus is thermotolerant, prolonged exposure to ~50C drastically reduces yield (Reyes-Rosales et al., 2023)

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doi: 10.1074/jbc.M010123200 25 BirdKARamosAAKliebensteinDJ

The RICE protocol (rest, ice, compression, elevation) remains appropriate initial management, with BPC-157 administration added to enhance the subsequent repair phase