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Regarding secondary outcomes, four out of five selected trials reported a significant reduction in body weight, BMI, and glycated hemoglobin levels in GLP-1 receptor agonist-treated participants

However, the authors urge caution in interpreting these findings due to the limited number of trials, the variations in study designs, and the heterogeneity in patient populations and substance types studied

The authors write that they suspect the two medications had synergistic effects in the patient, leading to adequate control of his blood sugars yet a state of starvation, ketone production, and resultant systemic acidification

GLP-1 receptor agonists are primarily used to treat type 2 diabetes by lowering blood sugar and reducing food intake

One major study called the FLOW trial found that GLP-1 medications reduced kidney problems by 24 percent in people with diabetes

Patient voice is much more important than any of us that are clinicians or experts in the field, she says