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While Pfizers oral GLP-1 candidate met its primary endpoint in a Phase IIb obesity trial, twice-daily dosing of danuglipron resulted in high rates of adverse events including nausea, vomiting and diarrhea

The overall heterogeneity for HHF was I 2 = 0% (95% uncertainty intervals, 0 and 48.0%) (null) (Additional file 1: Table S3), with no evidence of publication bias (Egger test, P = 0.413)

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The distinction between IM and subcutaneous is unlikely to be clinically meaningful given the absence of human pharmacokinetic benchmarks for either route

PMID: 25834231

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